Antipyrinum

Antipyrinum
(phenazone - a coal-tar derivative)
* Antipyrine is one of the drugs that induce leucocytosis, similar to ergotin, salicylates, and
tuberculin.
* Acts especially on the vaso-motor centers, causing dilation of capillaries of skin and
consequent circumscribed patches of hyperaemia and swelling.
* In large doses causes profuse perspiration, dizziness, cyanosis, and somnolence, albumen
and blood in urine.
* Acute erythema multiforme.
Mind
- Fear of becoming insane; nervous anxiety; hallucinations of sight and hearing.
Head
- Throbbing headache; sensation of constriction.
- Flashes of heat.
- Headache under ears with earache.
Eyes
- Puffiness of lids.
- Conjunctiva red and oedematous, with lachrymation.
- Red spots. [Apis.]
Ears
- Pains and buzzing.
- Tinnitus.
Face
- Oedema and puffiness.
- Red and swollen.
Mouth
- Swelling of lips.
- Burning of mouth and gums.
- Ulceration of lips and tongue; vesicles and bullae.
- Small lump in cheek.
- Tongue swollen.
- Bloody saliva.
- Toothache along lower jaw.
Throat
- Pain on swallowing.
- Expectoration of fetid pus.
- Abscess, white false membrane.
- Sensation of burning.
Stomach
- Nausea and vomiting; burning and pain.
Urine
- Diminished.
- Penis black.
Female
- Itching and burning in vagina.
- Menses suppressed.
- Watery leucorrhoea.
Respiratory
- Fluent coryza.
- Nasal mucous membrane swollen.
- Dull pains in frontal sinus.
- Aphonia.
- Oppression and dyspnoea.
- Cheyne-Stokes respiration.
Heart
- Faintness, with sensation of stoppage of heart.
- Throbbing throughout the body.
- Rapid, weak, irregular pulse.
Nerves
- Epileptiform seizures.
- Contractures.
- Trembling and cramps.
- Crawling and numbness.
- General prostration.
Skin
- Erythema, eczema, pemphigus.
- Intense pruritus. Urticaria, appearing and disappearing suddenly, with internal coldness.
- Angioneurotic-oedema.
- Dark blotches on skin of penis, sometimes with oedema.
Dose
- Second decimal potency.